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Image Search Results
Journal: Anesthesiology
Article Title: Iron Loading Exaggerates the Inflammatory Response to the Toll-like Receptor 4 Ligand Lipopolysaccharide by Altering Mitochondrial Homeostasis
doi: 10.1097/ALN.0000000000001653
Figure Lengend Snippet: Serum, lung and liver samples were harvested from C57Bl/6 mice treated with iron and/or LPS, and analyzed for serum Il6 (A), serum Tnfα (B) and mRNA levels of the two cytokines in the lungs (C–D) and livers (E–F). In each case, iron supplementation by itself did not induce inflammation. LPS alone induced increases in cytokine protein levels as well as mRNA levels. Serum cytokine levels in the control and iron treated groups were below the detection level of the assay in many cases. Iron administration significantly enhanced the effect of LPS induced inflammation in the mice. N = 7–9 mice per group. (Mann Whitney U test (2 A and B), and two-way ANOVA with Bonferroni’s post hoc tests (2 C–F, p values adjusted for all possible comparisons; Int: Interaction p value).
Article Snippet: Serum IL6 and TNF levels were measured using
Techniques: MANN-WHITNEY